Archive for the ‘Depression’ Category

Brain Plasticity: Learning to Rethink Drugs

Saturday, December 13th, 2008

An article in MIT’s Technology Review “Making an Old Brain Young: Scientists are developing new ways to manipulate the brain’s normal plasticity” caught my eye this week. From the title I thought this would be a serious review of the medical advances expected from therapies that leverage brain plasticity.

Unfortunately, the article focused entirely on the possibility for developing drugs that exploit plasticity.

I’m not against drugs. Drugs are amazing. One very immediate example in my life: My daughter has congenital hypothyroidism — without synthetic thyroid hormone she would have been severely disabled. The medical world should be evaluating drugs that leverage plasticity. What concerned me about the article was the lack of any mention of reference to non-drug therapies. At the moment such therapies seem to be appearing or surfacing thick and fast and can be used right now, without waiting for the drugs to be developed, tested and approved: The Australian Alzheimer’s Association has endorsed brain training exercises as a non-pharmacalogical mechanism for delaying or preventing the onset of Alzheimer’s symptoms. The most effective therapies for stroke victims leverage plasticity through non-drug therapies (see Drake and Taub). Many learning specialists now work with brain exercises to mitigate or correct learning dysfunctions rather than accommodations. And other research has shown that the generation of new nerve cells in the dentate gyrus helps combat depression — something that can be assisted with exercise and brain exercise…

Surely, if our newfound knowledge of plasticity teaches us anything it teaches us that non-drug therapies can achieve some remarkable results.

More on Depression And Brain Exercise

Tuesday, September 2nd, 2008

Here’s another article on the relationship between stimulating new neural growth and combatting depression. This one approaches the subject from the opposite perspective — that stress inhibits neural growth and can induce or exacerbate depression and reduce the effectiveness of antidepressant treatment.

(See previous post on how exercise and brain exercise can help combat depression.)

Antidepressants and Brain Structure

Sunday, August 31st, 2008

ScienceDaily reports on new research that Antidepressants Need New Nerve Cells To Be Effective. The study by researchers from UT Southwestern Medical Center showed that the effectiveness of anti-depressants in mice depended upon the growth of new nerves in the part of the brain called the dentate gyrus.

What does this tell us about exercise and brain exercise?

The dentate gyrus is one of the few areas of the brain thought to be able to generate significant numbers of new brain cells in a process known as neurogenesis, and scientists generally believe that this effect is enhanced by aerobic exercise. Apart from being associated with depression, it is also the region of the brain associated with memory formation.

Now, what does any of this have to do with brain exercise and working-memory training?

Well, it turns out that stimulation of working-memory also activates the dentate gyrus.  So, this would perhaps explain why those training with Brain Fitness Pro report greater levels of satisfaction and well-being. Another great reason to be brain-training.

Related Posts from Around the Web

Brain Structure & Mood Disorders – … to new ways to treat depression, bipolar disorder and other mental illnesses. Previously, researchers discovered that the hippocampus is smaller in depressed people, and that antidepressants actually enlarge the brain structure, …

Brain structure examined in mood disorder research – Previous research revealed that the hippocampus is smaller in depressed people, and that antidepressants enlarge the brain structure, possibly through a growth factor called brain derived neurotrophic factor (BDNF). …

Brain structure and depression – There have been many studies into the links between brain structure and depression. Particular emphasis has been placed on the limbic system, specifically the hippocampus and amygdala, which controls emotion and mood regulation. …